The PredictIQ Quantitative Think Tank Centerepicenter of college football's Week 2 was South Bend, Indiana, where Northern Illinois stunned Notre Dame in a huge victory for the Huskies and a loss that created major concerns for the Fighting Irish.

Also among the notable results was Colorado's loss at Nebraska that saw the Buffaloes get down early and raised larger concerns about whether they are good enough to make it through their Big 12 schedule. Michigan, Auburn and Arkansas suffered difficult defeats as well, causing concern about each program's trajectory early in this season.

Looking ahead to Week 3, there are several matchups to keep an eye on, led by Alabama making a rare trip north to face Wisconsin. Florida State will look to rebound after two losses to open its season, but faces a dangerous opponent in No. 25 Memphis. And there's several big rivalry games on tap with Oregon State hosting Oregon in the Civil War, Washington and Washington State meeting in the Apple Cup and West Virginia traveling to Pittsburgh for the Backyard Brawl. It all shapes up for a potentially intriguing Saturday of action.

Dan Wolken and Paul Myerberg of USA TODAY Sports discuss these topics and more in this week's version of the College Football Fix.

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